Inhibidores de puntos de control inmunológico: eventos autoinmunes y minería de datos
DOI:
https://doi.org/10.59681/2175-4411.v17.2025.1160Palabras clave:
minería de datos, inmunoterapia, inhibidores de puntos de control inmunológico, neoplasias, efectos colaterales y reacciones adversas relacionados con medicamentos, tecnología biomédicaResumen
Objetivo: investigar qué acontecimientos autoinmunes relacionados con el uso de inhibidores de puntos de control inmunitarios se han descubierto mediante la extracción de datos (ED) de la bibliografía. Método: Se utilizó una revisión rápida. Las bases de datos consultadas fueron la Biblioteca Virtual de Salud (BVS), Embase y Pubmed. Se seleccionaron quince estudios para el análisis. Resultados: los acontecimientos autoinmunes más frecuentes encontrados en la literatura a partir de la minería de datos sobre el uso de inhibidores de puntos de control inmunitarios fueron toxicidades renales, cutáneas, musculoesqueléticas, hematológicas, pulmonares, cardiacas y gastrointestinales, algunas de ellas mortales. Conclusión: con el uso de la inmunoterapia pueden producirse diversos eventos, lo que refuerza la necesidad de un seguimiento individualizado. Se sugiere que esta terapia sea investigada de acuerdo con el tipo de tumor, correlacionando con las características demográficas, así como el uso de tecnologías de la información para apoyar a los profesionales de la salud.
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Derechos de autor 2025 Natália Marmitt, Sheron Tannara Vargas, Agnes Peruzzo Innocente, Diogo Ferreira Ducatti, Gabriel Ricardo Fernandes, Alessandra Dahmer, Mellina da Silva Terres
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